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SOURCE Northwestern Medicine
New prostate cancer screening option combines existing tests to substantially increase accuracy
CHICAGO, Feb. 26, 2014 /PRNewswire-USNewswire/ -- Northwestern Medicine® is the first health care provider in the country to offer a new non-invasive blood test for prostate cancer that is nearly three times more accurate than the current standard prostate-specific antigen (PSA) blood test. Known as the Prostate Health Index (phi), the new test's accuracy will effectively remove the need for many men who test positive for elevated PSA levels to undergo a biopsy to achieve a reliable diagnosis.
According to the Centers for Disease Control and Prevention (CDC), prostate cancer is the most common type of non-skin cancer for men in America and is a leading cause of cancer death among men of all races. The most widely used screening test for prostate cancer is currently the PSA test, which measures the blood's level of PSA, a protein that is naturally produced by the prostate gland and is typically increased when cancer is present. While the PSA test is simple and non-invasive, its results can often indicate the possibility of prostate cancer when none is present.
"The PSA test is based on the fact that men with higher levels of the PSA protein are more likely to have prostate cancer," said William Catalona, MD, urologist at Northwestern Medicine and director of the Clinical Prostate Cancer Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. "The problem is that higher levels of PSA can also be caused by a benign enlargement or inflammation of the prostate, leading to many false-positives for cancer and ultimately unnecessarily invasive biopsies and an increased potential for patient harm."
In 2012, the U.S. Preventive Services Task Force called attention to the heightened risk of unnecessary patient harm caused by false-positives from PSA testing and released a recommendation calling for "a better test and better treatment options" for prostate cancer screening.
Because PSA testing isn't conclusive enough on its own, physicians normally advise men with increased PSA levels in the range of 4-10ng/mL to undergo a prostate biopsy. However, the phi test helps physicians distinguish prostate cancer from benign conditions by utilizing three different PSA markers (PSA, FreePSA and p2PSA) as part of a sophisticated algorithm to more reliably determine the probability of cancer in patients with elevated PSA levels. Because of the substantial increase in accuracy, results of a multi-center clinical study that Catalona led found a 31 percent reduction in unnecessary biopsies due to false-positives as a result of using the phi test.
In addition to being much more accurate and reducing the need for prostate biopsies, the new test also offers patients a screening option that still only requires a simple blood test. The phi test will become available to all healthcare providers within the first quarter of 2014, and was developed by Beckman Coulter and evaluated in a multi-center clinical research study lead by Catalona as the principal investigator.
For more information about the phi test for prostate cancer or to schedule an appointment, visit Northwestern Medicine's website or call 312-695-8146.
About Northwestern Medicine®
Northwestern Medicine® is the collaboration between Northwestern Memorial HealthCare and Northwestern University Feinberg School of Medicine around a strategic vision to transform the future of healthcare. It encompasses the research, teaching and patient care activities of the academic medical center. Sharing a commitment to superior quality, academic excellence and patient safety, the organizations within Northwestern Medicine comprise more than 9,000 clinical and administrative staff, 3,100 medical and science faculty and 700 students. The entities involved in Northwestern Medicine remain separate organizations. Northwestern Medicine is a trademark of Northwestern Memorial HealthCare and is used by Northwestern University.
About Northwestern Memorial Hospital
Northwestern Memorial is one of the country's premier academic medical center hospitals and is the primary teaching hospital of the Northwestern University Feinberg School of Medicine. Along with its Prentice Women's Hospital and Stone Institute of Psychiatry, the hospital has 1,705 affiliated physicians and 6,769 employees. Northwestern Memorial is recognized for providing exemplary patient care and state-of-the art advancements in the areas of cardiovascular care; women's health; oncology; neurology and neurosurgery; solid organ and soft tissue transplants and orthopaedics.
Northwestern Memorial has nursing Magnet Status, the nation's highest recognition for patient care and nursing excellence. Northwestern Memorial ranks 6th in the nation in the U.S. News & World Report 2013-14 Honor Roll of America's Best Hospitals. The hospital is recognized in 14 of 16 clinical specialties rated by U.S. News and is No. 1 in Illinois and Chicago in U.S. News' 2013-14 state and metro rankings, respectively. For 14 years running, Northwestern Memorial has been rated among the "100 Best Companies for Working Mothers" guide by Working Mother magazine. The hospital is a recipient of the prestigious National Quality Health Care Award and has been chosen by Chicagoans as the Consumer Choice according to the National Research Corporation's annual survey for 15 consecutive years.
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